adaptivedesign相关论文
The large scale building has large size,large energy consumption and complex function.With the rapid development of city......
An Adaptive Multi-stage Phase Ⅰ Dose-finding Design Incorporating Longitudinal Continuous Toxicity a
Phase Ⅰ designs traditionally use the dose-limiting toxicity(DLT),a binary endpoint based on the first treatment cycle,......
Repeated Measures Dose-Finding Design with Time Trend Detection in the Presence of Correlated Toxici
Background: Phase trials are designed to determine the safety,tolerability and recommended phase 2 dose of therapeutic a......
We propose a Bayesian phase Ⅰ/Ⅱ dose-finding trial design that simultaneously accounts for toxicity and efficacy.We mo......
Nowadays,Adaptive Bayesian Sequential Design(ABSD)has been increasingly applied in various phase Ⅰ and Ⅱ clinical tria......
This paper addresses dose finding in clinical trials where individuals exhibit biologic characteristics that alter the t......
An Adaptive Bayesian Sequential Design for Determining the Subject-Specific Optimal Treatment Length
While Bayesian adaptive designs have been widely used to find the optimal dose to be used in patients,and to select the ......
There are many challenges in clinical development for rare oncology disease.This talk will present a case study for a ra......
Simons optimal two-stage design has been widely used in early phase clinical trials for Oncology and AIDS studies wi......
